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Effect of Vasoactive Drugs on Tissue Blood Flow in the Hamster Melanoma¹

Department of Surgery, University Hospitals, University of Minnesota, Minneapolis, Minnesota

Previous quantitative estimates of blood flow of transplanted tumors have been lower than surrounding tissue. Using a modification of the Fick principle with antipyrine-¹³¹I, tissue blood flow was estimated in the hamster amelanotic melanoma implanted in subcutaneous tissue over the femoral triangle. Mean tumor blood flow was higher than adjacent tissue, decreased with tumor age, and responded uniquely to vasoactive drugs.

¹ This work was supported by American Cancer Society Grant T-156D.

Received 8/ 9/65. Revised 12/13/65.