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The Luteinizing Hormone in Growth and Differentiation of Experimental Ovarian Tumors¹

Department of Anatomy, College of Physicians and Surgeons, Columbia University, New York, New York

Castrated female mice bearing ovarian splenic implants were given rabbit antiserum to sheep luteinizing hormone 2 months after surgery. Controls received rabbit antiserum either to sheep follicle-stimulating hormone, beef albumin, or adjuvant. After treatment, implants from animals given anti-LH serum were undeveloped and undifferentiated and showed no evidence of gonadotropic stimulation. Controls were fully developed and frequently tumor-like, showing the effect of gonadotropic stimulation. The possibility that inhibition of implant growth and differentiation was due to a cross reaction between endogenous mouse gonadotropin and rabbit antiserum to sheep luteinizing hormone is discussed.

¹ Aided by Grant T-296 from the American Cancer Society and Grant DRG-537 from the Damon Runyon Memorial Fund.

² Research Associate in the Department of Anatomy.

Received 9/17/65. Revised 1/ 4/66.