This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Toth, B. Articles by Shubik, P. Search for Related Content PubMed PubMed Citation Articles by Toth, B. Articles by Shubik, P.

Carcinogenesis in Swiss Mice by Isonicotinic Acid Hydrazide¹

The Chicago Medical School, Institute for Medical Research, Division of Oncology, Chicago, Illinois

Administration of 0.1% isonicotinic acid hydrazide (INH) in drinking water to 9-week-old Swiss mice for the remainder of their lifetime resulted in the enhancement of pulmonary adenomas. The incidence rose from 14 to 53% in the females and from 10 to 42% in the males, as compared with the controls. The incidence of other tumors in these animals was not increased.

¹ This investigation was supported by Grant CS-9212 and Contract PH43-65-67 from the National Cancer Institute, NIH, USPHS.

Received 9/ 7/65. Revised 1/10/66.