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Studies on Hypophyseal Isografts in Mice¹

II. Properties of Polyribosomes

Departments of Biochemistry and Electrom Microscopy, Antoni van Leeuwenhoek-Huis; the Netherlands Cancer Institute, Amsterdam, the Netherlands

Polyribosomes, characterized by sedimentation behavior and electron microscopy, have been prepared from hypophyseal isografts in kidney. These preparations have incorporation ability for amino acids in vitro and can be stimulated for phenylalanine incorporation by polyuridylic acid, similar to the rat liver system. The 100,000 x g supernatant fraction contains a factor which protects the integrity of polyribosomes during incubation at 37°C.

¹ This investigation has been supported by a research grant, C-3431, from the National Cancer Institute, USPHS, Bethesda, Maryland.

² Present address: Department of Biochemistry, University of Nijmegen, the Netherlands.

Received 10/ 4/65.