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Chemoprophylaxis of Carcinogenesis: A Review

Department of Pathology, University of Minnesota Medical School, Minneapolis, Minnesota

A group of experiments is presented in which inhibition of chemical carcinogenesis in experimental animals has been achieved by administration of 1 of a variety of chemical compounds. The inhibitory compounds can be divided into 4 groups. The 1st group is composed of compounds which induce an increased activity of carcinogen-detoxifying systems; the 2nd, compounds with similar structures to carcinogens and which have been postulated to cause inhibition by a competitive mechanism; the 3rd, compounds which inhibit the initiation phase of carcinogenesis; and the 4th, a large number of compounds whose means of action is not clearly understood.

A major purpose of this review is to stimulate further work on the chemical inhibition of chemical carcinogenesis since this area of research appears to have considerable potential for yielding information of fundamental importance and conceivably might eventually have some applied aspects.

¹ Hill Professor, Department of Pathology, University of Minnesota.

Received 9/27/65. Revised 1/19/66.