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Sequential Hepatic Triglycerides in Tumor-bearing Mice¹

Department of Pathology and Institute of Experimental Pathology and Toxicology, Albany Medical College, Albany, New York

The hepatic triglycerides were serially determined following transplantation of glioma (Zimmerman ependymoma) in C57 black mice. During the first 2 days after tumor homogenate inoculation there was a sharp and progressive fall in hepatic triglycerides. Thereafter there was a transient increase in hepatic lipids followed by a return to the low levels previously observed. These biochemical changes could not be directly correlated with the size of the transplant.

The effects of starvation on hepatic triglyceride levels in animals with tumors 10, 5, and 0 days, respectively, after transplantation of tumor were determined. The sequential hepatic triglyceride patterns resembled the controls; however, they were progressively diminished in time and amplitude. Variations in the quantitative triglyceride patterns on successive analysis can be related to the combined sequential effects of the presence of this tumor in conjunction with the effects of starvation.

¹ This study was supported in part by USPHS Grant C-6248.

Received 6/ 8/65. Revised 2/ 3/66.