This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Bianco, A. R. Articles by Goldin, A. Search for Related Content PubMed PubMed Citation Articles by Bianco, A. R. Articles by Goldin, A.

Induction of Resistance against the Transplantation of Leukemias Induced by Rauscher Virus¹

Cancer Chemotherapy National Service Center, National Cancer Institute, Bethesda, Maryland

A state of relative resistance against the transplantation of isografts of leukemias induced by the Rauscher virus (RV) was developed in BALB/c and CDF₁ mice by pretreatment with X-irradiated tumor cells. In mice pretreated with cells from 1 tumor, significant cross-protection was obtained for all other RV-induced tumors tested and for some tumors induced by Moloney virus, but not for leukemia L1210. Although marginal resistance was observed on a few occasions, the inoculation of infectious RV was not an efficient method of inducing transplantation resistance in BALB/c and CDF₁ mice. In CDF₁ mice resistance to grafts of RV-induced tumors was accompanied by resistance to challenge with RV and the presence of circulating RV neutralizing antibodies.

¹ Presented in part at the 55th Annual Meeting, American Association for Cancer Research, Chicago, Illinois, April 9–11, 1964.

² Visiting Associate from Institute of Medical Pathology, University of Naples, Naples, Italy.

Received 11/ 8/65. Revised 2/28/66.