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Use of Lactate Dehydrogenase as a Marker in Rat-Mouse Chimera Studies¹

Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee

Rat cells contain lactate dehydrogenase isozymes that are different from the mouse isozymes. Therefore, in a rat-mouse chimera, any organ may be examined for the presence of rat-type cells.

¹ Research sponsored by the U. S. Atomic Energy Commission under contract with the Union Carbide Corporation.

² Present address: Wheeling College, Wheeling, West Virginia.

Received 12/ 2/65. Revised 3/24/66.