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Department of Bacteriology and Immunology, and Cancer Research Genetics Laboratory, University of California, Berkeley, California
Immunization of Strain A/Crgl female mice with living tissue and crude cell membrane preparations of recently arisen isogenic spontaneous mammary carcinomas conferred a marked degree of heightened reactivity against a subsequent challenge with the tumors. The heightened reactivity was manifested, under different experimental conditions, by either increased resistance or increased susceptibility to the tumor isografts. Increased tumor susceptibility could be transferred to normal isogenic hosts by means of serum from actively immunized animals and thus resembles the condition of immunologic enhancement. Experience with 1 tumor could evoke enhancement of another, indicating the existence of at least some cross-reacting antigens among spontaneous mammary carcinomas of this strain. Previous experience with living normal tissue or with normal cell membrane preparations of isogenic origin did not confer heightened tumor reactivity.
1 This work was supported by Research Grants AI-2309 and CA-05388 from the NIH, USPHS; E-344 and E-292 from the American Cancer Society; and by Cancer Research Funds of the University of California.
2 Present address: Department of Entomology, Faculty of Science, Cairo University, Giza, Egypt.
Received 12/21/65.
Revised 3/30/66.
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