This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Von Sallmann, L. Articles by Grimes, P. Search for Related Content PubMed PubMed Citation Articles by Von Sallmann, L. Articles by Grimes, P.

Thioacetamide-induced Cataract with Invasive Proliferation of the Lens Epithelium in Rainbow Trout

Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, NIH, USPHS, Bethesda, Maryland, and the Western Fish Nutrition Laboratory, Bureau of Sport Fisheries and Wildlife, Fish and Wildlife Service, United States Department of Interior, Cook, Washington

Cataracts developed in 90% of rainbow trout maintained on a thioacetamide diet for prolonged periods of time.

The most striking feature in the histology of these lenses was a massive proliferation of the lens epithelium and its transformation to a pleomorphic cell mass which sometimes replaced a great portion of the anterior lens cortex. The profuse invasion of the epithelial cells, their disorganization, and the presence of forms similar to Darier cells and epithelial pearls suggest a tumorous growth pattern.

The relation of the epithelial proliferation to fiber damage is not clear nor is the role of the carcinogenic properties of thioacetamide in the development of the lens pathology.

Received 1/20/66.