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Walker Carcinosarcoma 256 in Study of Anticancer Agents

I. Method for Simultaneous Assessment of Therapeutic Value and Toxicity¹

Described is the screening system with the Walker tumor in rats currently used at the Chester Beatty Research Institute. The biologic criterion of activity is defined in terms of the chemotherapeutic index measured in a combined therapeutic-toxicity assay.

¹ Supported by grants from the Medical Research Council and the British Empire Cancer Campaign for Research, and by grant CA-03188-08 from the National Cancer Institute, USPHS.

² Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, London, England.