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Induced Alteration of Resistance to Transplantable Mammary Adenocarcinoma in Mice Neonatally Inoculated with Rat Thymus Antiserum¹

Department of Preventive Medicine and Public Health and Department of Anatomy, University of Texas Medical Branch, Galveston, Texas

Two strains of Swiss mice have been utilized in this study. One strain of mice, designated as Strain R, has been relatively resistant to transplantable mouse adenocarcinoma (10% acceptance). The 2nd strain of mice (Strain S) from which the tumor was originally isolated, was used for maintenance and for comparative growth (80–100% acceptance). A series of young adult R mice, some neonatally inoculated with rat thymus antiserum (produced in rabbits) or normal rabbit serum along with a similar series of uninoculated control groups of R and S mice, were given implantations of adenocarcinoma tissue fragments. After 22 days of growth, 19 out of 28 adenocarcinoma implants were accepted (possibly delayed rejection) in the Group R mice treated with thymus antiserum. In the littermates treated with normal rabbit serum, only 1 tumor out of 24 implants was accepted and no tumors grew in the uninoculated R mice.

¹ This investigation was supported in whole by USPHS Research Grant 3R10-CA-08013-02-S1 from the National Cancer Institute.

Received 2/10/66.