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Hepatic Carcinogenesis in Thyroidectomized Rats: Apparent Blockade at the Stage of Initiation¹

Division of Oncology, Chicago Medical School, Chicago, Illinois, and the Department of Tumor Biology, University of Otago, New Zealand

The protective effect of thyroidectomy against the induction of liver tumors by 2-aminofluorene in rats is confirmed. Evidence is presented indicating that the effect of thyroidectomy may be attributable to blockade of liver carcinogenesis at or before the stage of initiation rather than to retardation of tumor progression in such animals.

¹ Supported by the New Zealand Cancer Society and by USPHS Contract PH-43-65.

Received 2/15/66.