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Effects of Prednisolone and Thalidomide on Induced Submandibular Gland Tumors in Hamsters¹

Department of Pathology, University of Pittsburgh School of Dentistry, Pittsburgh, Pennsylvania

No significant difference in the incidence of induced fibrosarcomas in hamster submandibular glands was noted when the animals were given a single intraglandular injection of 100, 200, 500, and 1000 µg of prednisolone concurrently with administration of 0.05 ml of 0.5% 7:12-dimethylbenz()anthracene (DMBA) in liquid petrolatum. There was, however, an inhibitory trend when, in addition to the initial intraglandular injection of 500 µg of prednisolone, the same amount was injected i.p. every week throughout the experiment. There was a higher but insignificant incidence of metastasis in prednisolone-treated hamsters as compared to the controls.

Thalidomide failed to show any influence on induced tumors when given to hamsters in a similar procedure using 3 dosage levels, a single 5- or 10-mg dose, and a 5-mg initial injection plus 5 mg/week.

¹ This investigation was supported in part by USPHS Grant 2 RO 1 HD00169-03, and in part by Health Research and Services Foundation Grant F-3.

² Present address: Department of Pathology, Capen Hall, State University of New York at Buffalo, Buffalo, New York.

Received 2/24/66.