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Erythropoiesis in Friend Leukemia: Red Blood Cell Survival and Ferrokinetics¹

Department of Medicine, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania

RBC survival and ferrokinetics were evaluated in Swiss Webster female mice infected with Friend virus. Infection causes a hemolytic anemia associated with reticulocytosis and a compensatory increase in erythropoiesis in the spleen. The RBC survival studies were performed by noncohort label (⁵¹Cr) and cohort label (⁵⁹Fe) technics. The anemia and shortened survival of RBC occurred in nonsplenectomized and splenectomized animals. Ferrokinetic studies did not reveal ineffective erythropoiesis. The data suggest a direct effect of the Friend virus on the RBC leading to a hemolytic anemia.

¹ This work was supported by the American Cancer Society, Grant No. E-305.

² Presently on leave of absence at the Walter Reed Army Institute of Research, Washington, D. C.

Received 7/ 2/65. Revised 3/ 4/66.