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Effect of Various Agents on Liver Regeneration and Walker Tumor Growth in Partially Hepatectomized Rats

Department of Biochemistry, Northwest Institute for Medical Research, 5656 West Addison Street, Chicago, Illinois 60634

Subtotally hepatectomized rats with Walker tumor transplanted into the caudal lobe of the remaining liver at surgery were administered agents which depress or increase the extent of regeneration over periods up to 10.5 days. Of the compounds stimulating liver weight restoration as such, diets supplemented with coramine, butazolidin, 2,4-dithiopyrimidine, thalidomide, and acenaphthene, or the latter hydrocarbon and 9,10-dimethyl-1,2-benzanthracene injected s.c., caused definite increases, whereas thiouracil, disulfiram, and usnic acid gave rise to liver increments which were in the range of the respective controls. Dietary supplements of the inhibitors, nicotinamide, cycloleucine, DL-ethionine, and 6-mercaptopurine or s.c. injection of cortisone acetate elicited decreases but these were not statistically significant. Accordingly, the presence of tumor tended to "normalize" the degree of regeneration. The mean wet tumor weights were not affected by any of the treatments except for a decrease with the diet containing nicotinamide (0.35%) and, possibly, with the 1 supplemented with cycloleucine (0.050%).

Received 11/ 4/65. Revised 3/28/66.