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Immunologic Acceleration of Death in Animals with Transplanted Tumors¹

Harvard School of Public Health, Tufts Medical School, and the Harvard Medical School, Boston, Massachusetts

In a previous publication, some prolongation of life was reported when DBA/1 mice were inoculated with Dbrb tumor 10 days after receiving an implant of a Millipore chamber containing rat lymph nodes sensitized against Dbrb tumor. In contrast, similar experiments with C57 mice and C-1498 tumor indicated that sensitized rat lymph tissue at times shortened survival while inhibiting tumor growth. The present studies with DBA/1 mice and also C3H mice and H-2712 tumor were done in an effort towards clarification of these findings. It appeared that a shortened survival by an accelerated death could be produced: (a) by increasing the amount of sensitized lymph nodes, (b) by hypersensitization of the rat to the mouse tumor before removing lymph tissue, or (c) by simultaneous challenge of the test animals with tumor inoculation and sensitized nodes. It is suggested that the heterologous transplantation of specifically sensitized lymph nodes caused a release of antibodies through the Millipore chamber for a brief period. An excessive antigen-antibody reaction then contributed to an accelerated, allergic type of death of the inoculated host. Gross and microscopic study of the tumors and major organs at autopsy tend to confirm this explanation.

¹ This work was performed, in part, under Grant CA-04337-05 from the NIH; from the American Cancer Society, Institutional Grant, Pittsburgh University, 951-252-11; and from Grant HD-01929, the National Institute of Child Health and Human Development, Department of Health, Education and Welfare.

Received 11/30/64. Revised 4/11/66.