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Chemotherapy of Leukemia L1210 in Mice with 1-ß-D-Arabinofuranosylcytosine Hydrochloride

II. Effectiveness against Intracerebrally and Subcutaneously Inoculated Leukemic Cells¹

Microbiological Associates, Inc. (I. K., D.D.T.), the Drug Evaluation Branch, Cancer Chemotherapy National Service Center, National Cancer Institute, NIH (J. M. V., A. G.), and the Biometry Branch, National Cancer Institute, NIH (N. M.), Bethesda, Maryland

The current studies illustrate that cytosine arabinoside (ara-C) is capable of increasing the survival time of mice bearing intracerebrally (i.c.) inoculated leukemia L1210.

The effect of ara-C, however, was more pronounced in the treatment of s.c. than i.c. inoculated leukemia L1210.

Bioassay experiments with brain tissues from ara-C-treated leukemic mice were conducted to examine the infectivity of leukemia after ara-C therapy. The treatment with ara-C against the lowest level of i.c. inoculum of L1210 cells resulted in "no takes" in recipient mice.

The eradication of leukemic cells in the brain by treatment with ara-C was also substantiated by an increased number of long term survivors, apparently free of leukemia, in groups of animals receiving a low concentration of leukemic cells given i.c.

The antileukemic efficacy of ara-C was similar to that of BCNU or BCM when those agents were given daily against i.c. inoculated disease.

¹ This study was supported by Contract PH-43-64-911 from the Cancer Chemotherapy National Service Center, NIH, USPHS. Some of these data were presented at the 56th Annual Meeting of the American Association for Cancer Research, Philadelphia, Pennsylvania, April 7–10, 1965 (7).

Received 1/ 3/66. Revised 4/20/66.