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Quantitative Aspects of the Reaction of Some Carcinogens with Nucleic Acids and the Possible Significance of Such Reactions in the Process of Carcinogenesis¹

Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, Fulham Road, London, England

Evidence for the reaction of alkylating agents, nitrosamines, azo-dyes, lactones, and hydrocarbons with nucleic acids in vivo is reviewed. Emphasis is placed on the quantitative aspect of such reaction, and on this basis the possible significance of the reaction with nucleic acids for the process of carcinogenesis is discussed.

¹ This work was supported by grants to the Chester Beatty Research Institute (Institute of Cancer Research: Royal Cancer Hospital) from the Medical Research Council and the British Empire Cancer Campaign for Research, and by USPHS Research Grant No. CA-03188-08 from the National Cancer Institute, USPHS.