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Antibodies Which React with Nucleic Acids¹

Department of Microbiology, Columbia University, New York, New York

During the past 5 years, several procedures for inducing antibodies capable of reacting with nucleic acids have been developed. These include immunization with phage lysates, ribosomes, purines, and pyrimidines or derivatives thereof coupled to proteins and polypeptides, denatured DNA or oligodeoxynucleotides complexed with methylated bovine serum albumin, and Gram-negative bacteria. It is now possible, therefore, to apply immunochemical procedures to the investigation of the chemical and biologic properties of nucleic acids, and some potential applications are discussed.

¹ These studies were supported, in part, by the USPHS (AI-01763) and Contracts NOnr 266(40) and NOnr 4259(11) between the Office of Naval Research and Columbia University.