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Cytotoxic Substances from Tropical Plants¹

Extracts of 177 species of tropical and subtropical plants were prepared and screened for cytotoxic activity against KB cells in tissue culture. Preparations from 12 plants had significant cytotoxic activity. The most active samples were isolated from Abrus precatorius.

¹ Supported by institutional research grants from the American Cancer Society and the Florida Division of the American Cancer Society, and by contract PH 43-64-890 from the Cancer Chemotherapy National Service Center, National Cancer Institute, USPHS.

² Department of Biology and School of Medicine, University of Miami, Florida.

³ Present address: Florida Atlantíc University, Boca Raton, Florida.