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Inhibition of DNA Synthesis in HeLa Cells by Hydroxyurea¹

Committee on Molecular Biology, and the Edward Mallinckrodt Institute of Radiology, School of Medicine, Washington University, St. Louis, Missouri

Hydroxyurea is a highly specific, rapidly acting inhibitor of DNA synthesis in HeLa S3 cells. It is without detectable effect on cells that are not synthesizing DNA. Incubation in inhibitory concentrations for as long as 19 hr does not kill cells in any phase of the division cycle. Rapid and complete reversal is accomplished simply by removing the drug from the culture medium.

¹ This investigation was supported by USPHS Research Grant No. CA-04483 from the National Cancer Institute.

² Trainee supported by USPHS Training Grant 5T1 GM-714.

Received 5/27/66. Accepted 8/18/66.

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