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Ultrastructural Changes Produced by Triparanol in Morris 5123 and Novikoff Hepatomas¹

Zoller Dental Clinic, University of Chicago, Chicago, Illinois 60637

Force feeding of large amounts of triparanol to rats bearing transplanted hepatomas results in appearance of myeloid bodies in liver cells and in hepatoma cells. The myeloid bodies are most numerous in liver cells, less abundant in the cells of Morris 5123 hepatoma, and rare in the cells of Novikoff hepatoma. The quantity of myeloid bodies can be correlated with development of endoplasmic reticulum and with duration of treatment.

¹ Supported by a fellowship of the Zoller Memorial Dental Clinic.

Received 4/ 6/66. Accepted 8/19/66.