This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hoffmann, D. Articles by Wynder, E. L. Search for Related Content PubMed PubMed Citation Articles by Hoffmann, D. Articles by Wynder, E. L.

The Reduction of the Tumorigenicity of Cigarette Smoke Condensate by Addition of Sodium Nitrate to Tobacco¹

Division of Environmental Cancerigenesis, Sloan-Kettering Institute For Cancer Research, New York, New York

The tumorigenic activity of cigarette smoke condensate and the concentrations of certain selected chemical constituents in the smoke of cigarettes treated with 8.3% NaNO₃ are compared with those of a standard (untreated) cigarette. The NaNO₃ treatment resulted in a significant reduction of particulate matter and also a statistically significant selective reduction of nicotine, phenol, and benzo(a)pyrene in the smoke as compared with the untreated cigarette.

Smoke condensate from the treated cigarette proved to be less toxic and gave a significantly lower tumor yield than the condensate from the standard cigarette. The academic and practical aspects of these findings will be discussed.

¹ This work was supported by the Research Grant E-231 from the American Cancer Society and in part by the Institutional Grant CA-08748 from the National Cancer Institute, NIH.

Received 6/20/66. Accepted 8/19/66.

This article has been cited by other articles:

				J. Laitakari and F. Stenback Collagen Matrix in Development and Progression of Experimentally Induced Respiratory Neoplasms in the Hamster Toxicol Pathol, August 1, 2001; 29(5): 514 - 527. [Abstract] [PDF]

				A Rodgman, C J Smith, and T A Perfetti The composition of cigarette smoke: a retrospective, with emphasis on polycyclic components Human and Experimental Toxicology, October 1, 2000; 19(10): 573 - 595. [Abstract] [PDF]

				D. Hoffmann and E. L. Wynder Smoke of Cigarettes and Little Cigars: An Analytical Comparison Science, December 15, 1972; 178(4066): 1197 - 1199. [Abstract] [PDF]

				J. H. Terrell and I. Schmeltz Cigarettes: Chemical Effects of Sodium Nitrate Content Science, June 28, 1968; 160(3835): 1456 - 1456. [Abstract] [PDF]