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Preliminary Report on Virus-like Particles in Canine Leukemia and Derived Cell Cultures¹

Departments of Anatomy, Pathology and Microbiology, University of Kansas School of Medicine, Kansas City Field Station, Communicable Disease Center, Public Health Service, United States Department of Health, Education, and Welfare, Kansas City, Kansas; and the Department of Pathology, Menorah Medical Center, Kansas City, Missouri

A light and electron microscopic study was made of lymphatic tissues from 2 dogs with reticulum cell leukemia. Virus-like particles were found in both dogs. Cultures of leukemic cells were established from both dogs and 1 culture contained numerous C type virus-like particles. Mycoplasma canis was recovered from the pleural fluid and pleural fluid cell culture of 1 dog. Comparison of this mycoplasma with the virus-like particles showed the former to be more pleomorphic and much larger. M. canis was eliminated from the cell culture and the particles seen in subsequent passages were assumed to be viral rather than a form of mycoplasma.

¹ This investigation was supported in part by USPHS Grant Nos. CA 06985-03, CA 04888-06, and 2 T1 AI 137-06 and the University of Kansas Institutional Cancer Grant No. 63R-1224-3.

Received 5/17/66. Accepted 7/18/66.

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