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Subcutaneous Sarcomas in Wistar Rats following Single 3-Methylcholanthrene Ingestion at Age 8–15 Days¹

Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania

Wistar rats were given a single intragastric dose of 2–5 mg of 3-methylcholanthrene at age 8–15 days. Five of 16 females and 6 of 10 males developed sarcoma, of which 5 were in the cervical and 4 in the axillary subcutaneous areas, and 1 each in the vaginal and thoracic region. Two of the 11 tumors contained liposarcomatous elements. There were no epithelial neoplasms of the breast, sebaceous glands, or skin, nor leukemias.

¹ This work was supported in part by Grant CA-07771 from the National Cancer Institute, NIH, USPHS.

Received 6/13/66. Accepted 8/17/66.