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Combination Therapy of 3-Methylcholanthrene-induced Mammary Carcinoma in Rats: Effect of Chemotherapy, Ovariectomy, and Food Restriction¹

Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania

The growth of mammary carcinoma induced by oral 3-methylcholanthrene in female Wistar rats is retarded by ovariectomy and by food restriction sufficient to produce 12–14% body weight loss. Estradiol benzoate (NSC 9566), 5-fluorouracil (NSC 19893), miracil D (NSC 14574), mitomycin C (NSC 26980), and AB-100 (NSC 37095) showed inhibitory activity. The best tumor inhibition without mortality was elicited by ovariectomy combined with food restriction, and by ovariectomy combined with estradiol benzoate.

¹ Supported by Contract SA-43-ph-4344 from the Cancer Chemotherapy National Service Center, National Cancer Institute, NIH, USPHS.

Received 5/ 9/66. Accepted 7/18/66.