This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Johnson, R. E. Search for Related Content PubMed PubMed Citation Articles by Johnson, R. E.

Radiosensitivity of Leukemic and Nonleukemic Lymphocytes

Radiation Branch, National Cancer Institute, NIH, Bethesda, Maryland

Ten patients with chronic lymphocytic leukemia and 13 patients with nonleukemic diagnoses have been treated with total body radiation in small divided doses. The response of the hemoglobin count, platelet count, and absolute neutrophil count was similar for both groups of patients. The absolute lymphocyte counts were markedly reduced in the leukemic patients as compared to the nonleukemic patients. Similar changes were observed in the bone marrow. The fractionated dosage schedules provided a high therapeutic ratio and resulted in an apparently normal or nearly normal morphologic state in the peripheral blood and bone marrow of several patients with chronic lymphocytic leukemia.

Received 4/20/66. Accepted 7/19/66.