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Carcinogenesis in AKR Mice Injected at Birth with Benzo(a)pyrene and Dimethylnitrosamine¹

The Chicago Medical School, Institute for Medical Research, Division of Oncology, Chicago, Illinois

Newborn AKR mice were injected s.c. with either 200 µg of benzo(a)pyrene (BP) or with 30 µg of dimethylnitrosamine (DMN). The BP was found to result in a more rapid occurrence of malignant lymphomas than observed in the controls and to result in many lung adenomas. The DMN had no apparent effect on the development of virally mediated lymphomas but resulted in the appearance of benign and malignant liver tumors and lung adenomas.

¹ This investigation was supported by Grants CS-9212 and CA-4665 from the National Cancer Institute, NIH, USPHS.

Received 5/12/66. Accepted 7/19/66.