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Effects of Dietary Fat on Mammary Carcinogenesis by 7,12-Dimethylbenz()anthracene in Rats¹

The Collip Medical Research Laboratory, University of Western Ontario, London, Ontario, Canada

A semisynthetic high-corn oil diet enhanced the development of mammary cancer induced by 7,12-dimethylbenz()anthracene (DMBA) in intact female Sprague-Dawley rats. This was in comparison to two other groups of similarly treated rats fed a high-coconut oil and a low-fat semisynthetic diet, respectively. The average daily caloric intake was similar, and the average growth rate, based on body weight, was comparable in all three groups.

Fatty acid analyses demonstrated that, at the time of DMBA administration, the composition of mammary fat was different in the three different groups, reflecting their dietary fat intake.

The data from this study suggest that dietary effects upon DMBA mammary carcinogenesis were related to the nature as well as the amount of fat used.

¹ This study was supported by a grant from the Ontario Cancer Treatment and Research Foundation.

² Medical Research Associate, Medical Research Council of Canada.

Received 2/13/67. Accepted 5/22/67.