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Basophil Adenomata in the Pituitary Glands of 2-year-old Male Long-Evans Rats

Endocrinology Research Department of the Medical Research Council of N.Z., University of Otago Medical School, Dunedin, New Zealand

Pituitaries of male and female Long-Evans rats were examined two years after internal or external thyroid radiation.

Treatment with radioiodine significantly increased the numbers of thyrotropic pituitary cell adenomata in both sexes. No increase in the numbers of such adenomata followed the X-irradiation of the male thyroid glands in the doses used. Gonadotropic cell adenomata were found in 74% of male rat pituitaries. The incidence was not affected by thyroid irradiation. In the female rat pituitaries, the incidence of gonadotropic cell adenomata was only 3%.

On the basis of cytoplasmic granule characteristics, most of the gonadotropic cell adenomata could be homologized with follicle-stimulating hormone cells or with luteinizing hormone cells.

Received 10/17/66. Accepted 5/29/67.