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Treatment of Malignant Melanoma with Hydroxyurea¹

Department of Medicine, Columbia University College of Physicians and Surgeons, and the Medical Services of the Columbia-Presbyterian Medical Center and the Francis Delafield Hospital, New York, New York 10032

Hydroxyurea was administered in a clinical trial to fourteen patients with documented disseminated malignant melanoma. The drug was not found to be useful as the sole agent in this neoplastic disorder in the dosage regimen outlined. The response of three patients receiving radiotherapy to metastatic brain lesions in combination with hydroxyurea was encouraging enough to warrant a further evaluation of this type of combination therapy.

¹ This work was supported in part by USPHS Grants CA 02332 and CA 04346 from the National Cancer Institute, The Hyman Goldburg Memorial Fund, and the Irving Wershaw Memorial Fund.

Received 2/ 6/67. Accepted 6/ 5/67.