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A Search for Urinary 4',10-Dimethyl-1,2-benzanthracene and Other Hydrocarbons¹

Department of Chemistry, University of Mississippi, University, Mississippi 38677

Twenty-four-hour urine specimens from normal men, pregnant women, and patients with a variety of cancers were examined by ultraviolet spectrophotometry and gas-liquid chromatography for the presence of benzanthracenes (especially 4',10-dimethyl-1,2-benzanthracene) and of n-alkanes. No benzanthracene could be detected. The limit of detection was about 1 µg/24-hr specimen. The amount of n-alkanes did not exceed 20 µg/24-hr specimen. A urinary substance from patients with melanoma was found which, on the basis of its ultraviolet spectrum, does not appear to have been reported earlier.

¹ The support of this investigation by Research Grant P-292 of the American Cancer Society is gratefully acknowledged. We also wish to thank the Cancer Chemotherapy National Service Center for underwriting the cost of the total synthesis of 4',10-dimethyl-1,2-benzanthracene.

Received 1/23/67. Accepted 6/16/67.