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Association of Embryonic Antigens with Experimentally Induced Hepatic Lesions in the Rat

Laboratoire de Chimie des Protéines, Institut de Recherches Scientifiques sur le Cancer, CNRS, Villejuif, Seine, France

Short-term hepatic injury was produced in rats by single i.p. injections of N-dimethylnitrosoamine, carbon tetrachloride, and cadmium sulfate, or by partial hepatectomy. In all cases, the animals responded with varying serum titers of embryonic ₂-glycoprotein which could be detected as early as 24 hours after the treatment. Antigen LA, another embryonic constituent, was never detected under the above conditions. Long-term hepatic injury was produced by oral ingestion of carcinogenic aminoazo dyes, N-dimethylnitrosoamine and aflatoxin B₁, and by noncarcinogenic analogs of aminoazo dyes. The lesions induced were those classically obtained following such treatments: hepatocarcinoma, bile-duct carcinoma, cirrhosis, hepatitis, etc. The embryonic ₂-glycoprotein was associated with all these lesions, whereas Antigen LA was specifically associated with rats bearing hepatocarcinomas. Neither Antigen LA nor the ₂-glycoprotein were found in rats bearing tumors of other organs than the liver. Lipoprotein-esterase was increased in the majority of sera of rats with these various hepatic lesions.

Received 1/16/67. Accepted 6/16/67.