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The Production of Carcinoma of the Urinary Bladder in Rats by Feeding N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide¹

^[1] Division of Clinical Oncology, University of Wisconsin Medical School, Madison, Wisconsin 53706
^[2] Department of Organic Chemical Research, Scientific Divisions, Abbott Laboratories, North Chicago, Illinois 60064

Thirty female Sprague-Dawley rats were fed 0.188% of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide for 46 weeks. Twenty-nine of the rats lived 34 weeks or more and all of these animals developed gross bladder carcinomas. Three rats developed carcinomas of the renal pelvis which invaded the kidney. There were 15 animals with 1 or more gross mammary tumors, all of which were classified as benign adenoma, fibroadenoma, or adenofibroma. This is the first nitrofuran derivative which has been found to be a bladder carcinogen, and the compound appears to be one of the most effective bladder carcinogens for this species.

¹ This research was supported by a grant from the American Cancer Society and Contract No. PH 43-66-888 from the National Cancer Institute.

² American Cancer Society—Charles S. Hayden Foundation Professor of Surgery in Cancer Research.

³ Present address: Pahlavi University, Department of Biochemistry, c/o American Peace Corps, Khiaban Zand, Kucheh Yaghma, Shiraz, Iran.

Received 3/20/67. Accepted 6/22/67.