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Influence of 3-Methylcholanthrene on Liver Carcinogenesis in Rats Ingesting DL-Ethionine, 3'-Methyl-4-dimethylaminoazobenzene, and N-2-Fluorenylacetamide¹

Department of Pathology, Nara Medical University, Kashihara, Nara, Japan, and the Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213

The purpose of this study was to observe whether the administration of 3-methylcholanthrene (3-MC) would influence the development of liver cancer by ethionine. Unlike the prevention by 3-MC of liver cancer induction by 3'-methyl-4-dimethylaminoazobenzene or 2-fluorenylacetamide, 3-MC had no evident influence upon the development of preneoplastic or neoplastic changes in the liver induced by ethionine. These findings are consistent with the conclusion that metabolism of ethionine by microsomal enzymes is not essential for liver carcinogenesis with this methionine analog.

¹ Supported in part by research grants from the American Cancer Society and the Beaver County Cancer Society and by USPHS Research Grant CA-06074 from the National Cancer Institute. A preliminary report of some of this research has been published (10).

Received 3/ 6/67. Accepted 6/22/67.