This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Chang, J. P. Articles by Ichinoe, K. Search for Related Content PubMed PubMed Citation Articles by Chang, J. P. Articles by Ichinoe, K.

Establishment of Transplantable Hepatomas Induced by 3'-Methyl-4-dimethylaminoazobenzene with Special Reference to the Histologic Features of the Transplants of Early Passages¹

Department of Pathology, The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025

Several lines of transplantable hepatomas induced by feeding rats 3'-methyl-4-dimethylaminoazobenzene have been established in this laboratory. The primary tumor cells were placed into an air pouch on the back of recipients that were previously conditioned by intramuscular injections of cortisone. This technic is reproducible. If desired, a new transplantable tumor line can be produced almost at will. The resultant transplantable hepatomas which were derived from the two main types of primary tumors, the adenocarcinoma and the trabecular carcinoma, exhibited different biologic behavior and histologic features. Significant morphologic changes occurred in the tumor cells of the first two passages especially if the tumor was of adenocarcinomatous origin. After a few passages these tumors became less differentiated and more stable.

¹ Supported by USPHS Grant CA 05312 from the National Cancer Institute. Reported in part at the 9th International Cancer Congress, Tokyo, Japan, October 23–29, 1966.

² Present address: Pennsylvania College of Podiatry, Eighth and Pine Streets, Philadelphia, Pennsylvania.

³ Present address: Hokkaido University Medical School, Sapporo, Japan.

Received 12/29/66. Accepted 6/23/67.