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Corticosteroid Production Rates in Strain 2 Guinea Pigs following L₂C/NB Leukemia Transplantation¹

^[1] Worcester Foundation for Experimental Biology, Inc., Shrewsbury, Massachusetts 01545
^[2] Veterans Administration Central Office, Washington, D. C., and Department of Research Pathology, Georgetown University Medical Center, Washington, D. C.

Production rates of cortisol, 2-hydroxycortisol, and 6ß-hydroxycortisol were determined (by isotope dilution technics) in individual adult Strain 2 guinea pigs following transplantation of the guinea pig lymphoblastic leukemia L₂C/NB. There was a statistically significant (P < 0.01, 0.02, and 0.01) 2.0-, 1.4-, and 1.9-fold higher production of cortisol, 2-hydroxycortisol, and 6ß-hydroxycortisol, respectively, in leukemic guinea pigs in comparison with similarly treated controls. No statistically significant change was observed in the fraction of the total cortisol production converted peripherally to 2- and 6ß-hydroxycortisol. The results indicate that in leukemic animals there was an increased adrenal secretion of 6ß-hydroxycortisol but not of 2-hydroxycortisol.

¹ This investigation was supported in part by USPHS Research Grant CA-05466 and Research Career Development Award 1-K3-CA-3949 from the National Cancer Institute and Research Grant P-293 from the American Cancer Society (to S. B.).

Received 3/ 9/67. Accepted 6/29/67.