This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Gropper, L. Articles by Shimkin, M. B. Search for Related Content PubMed PubMed Citation Articles by Gropper, L. Articles by Shimkin, M. B.

Chemotherapeutic Response of 3-Methylcholanthrene-Induced Mammary Carcinoma in Wistar Rats to 51 Agents¹

Fifty-one chemical agents were tested for antitumor activity against mammary carcinoma induced by gastric instillations of 3-methylcholanthrene (NSC-21970) in female Wistar rats. Eight agents were active, that is, the tumor weight of treated animals at 42 days was less than 50% of the tumor weight in untreated controls (T/C < 0.5), without significant mortality or body weight loss in the treated animals. These agents were: colchicine (NSC-757); 4,4'-(1,2-diethylethylene)diphenyl hexestrol (NSC-9894); 17-hydroxy-6-methylpregn-4-ene-3,20-dione acetate (NSC-26386); 5-bromo-2'-deoxyuridine (NSC-38297); 1-ß-D-arabinofuranosylcytosine, monohydrochloride (NSC-63878); 6ß-(dimethylamino)-3ß, 5-dihydroxy-5-pregnan-20-one (NSC-73862), 1-adamantine hydrochloride (NSC-83653); and 1,4-dimethyl-1,4-diphenyl-2-tetrazene (NSC-83799).

¹ Supported by contract SA-43-ph-4344 from the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, USPHS.

² Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania.