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Lack of Urothelial Topical Tumorigenicity and Cotumorigenicity of Schistosome Ova in Mice¹

The Henry C. Buswell Urologic Research Laboratory and Division of Urology, Department of Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York

Lyophilized Schistosoma haematobium ova in mineral oil suspension did not exert a topical carcinogenic effect on mouse bladder epithelium in 44 weeks. When methylcholanthrene was incorporated in the ova suspension, small numbers of transitional and squamous neoplasms were observed.

¹ Supported in part by an institutional grant from the American Cancer Society.

Received 6/ 9/66. Accepted 9/ 1/66.

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