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Effect of Vitamin A on 7,12-Dimethylbenz()anthracene-induced Papillomas in Rhino Mouse Skin¹

Skin and Cancer Hospital, Temple University Health Sciences Center, Philadelphia, Pennsylvania

Rhino mice fed a diet containing 100 IU of vitamin A per gm of feed produced fewer papillomas than did similar mice fed a diet deficient in vitamin A, following a single topical dose of dimethylbenzanthracene. The differences were due at least in part to more rapid loss of papillomas in the vitamin-A-supplemented animals. Within a single dietary group the rate of loss was linearly dependent on the total number of papillomas produced, but this rate was substantially higher in supplemented animals. Both appearance and loss of papillomas were linear functions of time, in supplemented animals, whereas the rates in nonsupplemented animals appeared to be of higher orders.

¹ This investigation was supported by USPHS Research Grant No. CA-07957-01 from the National Cancer Institute.

Received 5/ 3/66. Accepted 9/ 1/66.

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