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Radiosensitivity of Drug-resistant L1210 Leukemia

Radiation Branch, National Cancer Institute, NIH, Bethesda, Maryland

The radiation response of murine L1210 leukemia was examined. Radiation dose-survival curves demonstrated that nondividing (resting) leukemic cells and logarithmically proliferating leukemic cells were equally radiosensitive. A radiosensitive state was also demonstrated for 2 drug-altered leukemia cell lines, 1 strain being markedly resistant to antimetabolite therapy and the other having a decreased growth rate following exposure to an alkylating agent. These studies indicate that cross-resistance does not exist in this experimental system under conditions where drug resistance is present.

Received 6/ 8/66. Accepted 9/ 1/66.