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Sex-linked Inhibition of Tumors by Pyruvaldehyde Bis(thiosemicarbazone)¹

Division of Experimental Chemotherapy, Division of Special Studies, and Division of Biological Chemistry, Sloan-Kettering Institute for Cancer Research, and the Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, Medical College, New York, New York

The tumor-inhibitory effect of pyruvaldehyde bis(thiosemicarbazone) was greater on 6 tumors carried in male mice and rats than in females. The effect of the compound on Walker 256 in castrated male rats was similar to that seen in females. In castrated males, the antitumor activity was less than that in normal males. The injection of estradiol in such castrated males did not alter the effect. However, injection of testosterone restored the castrated animals to the same degree of response as normal males. In female animals, ovariectomy decreased the activity of pyruvaldehyde bis(thiosemicarbazone). Concurrent administration of testosterone to ovariectomized animals resulted in antitumor activity comparable to that seen in males. The increased activity seen in males and animals receiving testosterone was achieved without increase in systemic toxicity.

¹ This study was supported in part by funds from National Cancer Institute Grant CA 08748.

Received 5/16/66. Accepted 9/27/66.

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