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Chromosome Studies of 8 in Vitro Lines of Burkitt's Lymphoma¹

Division of Pathology, Sloan-Kettering Institute for Cancer Research, and Memorial Hospital, New York, New York

Of 8 Burkitt lymphoma lines, 4 had classically diploid stemlines, Ogun and Kudi being female, and Raji and EB3, male. EB2 was diploid but with an abnormal near-metacentric marker. SL₁ was diploid but with 3 markers. EB1 was subdiploid. Jiyoye was normal male except for trisomy for a 6–12+X chromosome.

As compared with benign cells, the lines tended to show a high incidence of aberration including markers, multiradials, and pulverized metaphase figures. A sporadic marker, RM-1, has been observed in SL₁, Jiyoye, and Ogun. Distinctive secondary constrictions occur on a pair of 6–12+X homologs in EB2, EB3, and Jiyoye.

¹ This work was supported by Grant DRG 798 from the Damon Runyon Memorial Fund for Cancer Research and by NCI CA08748.

² Present address: Pathology Department, University of Utah Medical Center, Salt Lake City, Utah.

Received 6/24/66. Accepted 9/28/66.

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