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Transplantation of Lymphosarcoma in Calves¹

School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, and The Institute for Medical Research, Camden, New Jersey 08103

Bovine lymphosarcoma cells were transplanted into six newborn calves which had first received 200 rads of whole-body irradiation. Distinct subcutaneous masses, involving one or more prefemoral and/or prescapular lymph nodes, were evident within one or two weeks after inoculation of lymphosarcoma cell suspensions. In each instance, it was possible to make a histologic diagnosis of lymphosarcoma and, with the exception of one calf in which cytogenetic studies were not attempted, to demonstrate by chromosome analysis that the cells were of donor origin.

Whereas some of the transplanted lymphosarcomas regressed following recovery from the effects of irradiation, four of the calves were found to have multiple tumors at autopsy.

¹ This study was conducted under Contract No. 43-65-1013 within the Special Virus Leukemia Program of the National Cancer Institute, NIH, USPHS.

Received 7/21/66. Accepted 10/20/66.