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The Effects of Fibroblasts on the Colonial Morphology of HeLa Cells¹

Department of Medicine and Eugene C. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska College of Medicine, Omaha, Nebraska 68105

Fibroblastic cell strains frequently induce a change in the percentage distribution of HeLa cell colonial types. This change consists of increasing the percentage of compact or loose HeLa cell colonies when compared to controls. Most human fibroblastic cell strains from malignancies increase HeLa cell compact colonies, whereas cell strains from human embryonic tissues increase diffuse colonies. The change in frequency distribution of HeLa cell colonial types induced by a fibroblastic cell strain from a given tissue is similar from one human to another as evidenced by the strains derived from skin, lung, foreskin, chorion, and carcinoma of the breast. Work is progressing to elucidate the factor or factors responsible for these changes.

¹ This work was supported by Grant No. P-359 from the American Cancer Society.

Received 6/22/66. Accepted 10/24/66.