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Evaluation of Tryptophan Mustard (NSC-62403) in Patients with Plasmacytic Myeloma

^[1] Mayo Clinic, Rochester, Minnesota 55901
^[2] National Cancer Institute, Bethesda, Maryland 20014
^{[3, 10]} Georgetown University School of Medicine, Washington, D. C.
^[4] Johns Hopkins Hospital, Baltimore, Maryland 21205
^{[5, 11]} Roswell Park Memorial Institute, Buffalo, New York
^[6] New York Hospital, New York, New York
^[7] Mount Sinai Hospital, New York, New York
^[8] West Virginia University Medical Center, Morgantown, West Virginia 26505
^[9] Rhode Island Hospital, Providence, Rhode Island 02908
Bowman Gray School of Medicine, Winston-Salem, North Carolina; National Cancer Institute, Baltimore, Maryland; Coney Island Hospital, Brooklyn, New York 11235; Lemuel Shattuck Hospital, Jamaica Plain, Massachusetts 02130; Albany Medical College of Union University, Albany, New York 12208; Dartmouth Medical School, Hanover, New Hampshire 03755

Tryptophan mustard, 0.3 mg/kg i.v. once weekly, was given to 38 patients with plasmacytic myeloma. Of these, 27 were treated for 30 days or more and therefore were considered to be eligible for evaluation of response. Improvement in one or more parameters occurred in 14 patients. Six patients received benefit in two parameters or more. Toxicity consisted of leukopenia and thrombocytopenia but this did not cause serious complications. Nausea and vomiting occurred in 18 patients and necessitated cessation of therapy in 4. Tryptophan mustard appears to possess activity against plasmacytic myeloma and may be useful when other therapy has failed.

Received 8/29/66. Accepted 10/24/66.