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Liver and Serum Vitamin B₁₂ Concentration of Rat during Ingestion of 3'-Methyl-4-dimethylaminoazobenzene¹

Department of Pathology, The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025

The sequential changes in the liver and serum vitamin B₁₂ levels of rats receiving 3'-methyl-4-dimethylaminoazobenzene have different patterns during the first ten days in comparison to the subsequent period of ingestion of the dye. During the first week of feeding there is a transient increase in liver B₁₂ and a reduction of serum B₁₂. A similar increase in liver B₁₂ and a reduction of serum B₁₂ also occurs in fasting rats. In contrast, rats fed the dye over a long duration have lower vitamin B₁₂ levels throughout the period of dye-feeding in comparison to the control animals. A possible explanation for this is discussed.

¹ This investigation was supported by USPHS research grant CA-05312, grant C-5065, and by Research Career Development Award SF-288 to V. M. Doctor from USPHS.

² Present address: Department of Chemistry, University of Houston, Houston, Texas.

Received 6/30/66. Accepted 10/27/66.