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A Controlled Comparison of 5-Fluoro-2'-deoxyuridine Therapy Administered by Rapid Intravenous Injection and by Continuous Intravenous Infusion¹

Mayo Clinic and Mayo Foundation, Section of Medicine (C.G.M., R.J.R.) and of Oncology (R.G.H.), Rochester, Minnesota 55901

A comparison of the results of 5-fluoro-2'-deoxyuridine (FUDR) therapy administered by rapid i.v. injection with those of FUDR administered by 24 hr constant infusion in patients with inoperable or metastatic carcinoma of the large bowel indicates that each method of administration produces its own distinctive toxicity pattern. However, evaluation of objective therapeutic results revealed that continuous-infusion therapy was significantly inferior to therapy by rapid injection.

¹ This investigation was supported in part by the Minnesota Division of the American Cancer Society.

Received 8/ 1/66. Accepted 10/27/66.