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Mechanism of Action of Streptonigrin in Leukemic Cells¹

Duke University Medical Center, Durham, North Carolina 27705

Streptonigrin (SN) was found to dissociate the formation of adenosine triphosphate from oxygen consumption in human leukemic leukocytes. SN caused a decrease in adenosine triphosphate and protein synthesis of intact cells and resulted in strand breakage of extractable DNA. SN did not inhibit ribosomal protein synthesis. It is suggested that the marked effects of SN on cellular metabolism are primarily attributable to the catalytic oxidation of reduced diphosphopyridine nucleotide and the resultant peroxide formation.

¹ This work was supported in part by grants from the American Cancer Society (P-363) and the National Science Foundation (GB-1416).

² USPHS Trainee (T4 CA5042).

³ USPHS Career Development Awardee (5-K3-GM-4857).

Received 9/ 2/65. Accepted 11/15/66.